Multigenerational silencing dynamics control cell aging
نویسندگان
چکیده
منابع مشابه
Multigenerational silencing dynamics control cell aging.
Cellular aging plays an important role in many diseases, such as cancers, metabolic syndromes, and neurodegenerative disorders. There has been steady progress in identifying aging-related factors such as reactive oxygen species and genomic instability, yet an emerging challenge is to reconcile the contributions of these factors with the fact that genetically identical cells can age at significa...
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Aging is manifested by a progressive decline in vitality over time leading to death. Studies in budding yeast allow aging to be followed in individual pedigrees of cells, that is, those of mother cells, consequent to many rounds of cell division (Mortimer and Johnston 1959). These studies have led to the general conclusion that the silencing protein Sir2 is a limiting component of longevity; de...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1703379114